Shanshuang Chen

The paper investigates the binding of scorpion toxin CTX to the MthK channel using cryo-EM, NMR, and MD simulations to explain toxin affinity and subtype tolerance.

This study determines cryo-EM structures of B0AT2 to elucidate substrate recognition and allosteric inhibition mechanisms, revealing conserved intracellular cavities across SLC6 transporters.

This study uses cryo-EM and solid-state NMR to determine the structure and dynamics of MscL from E. coli, revealing lipid-protein interactions that drive mechanosensitive gating.