Author

Jing Xue

Howard Hughes Medical InstituteORCID 0000-0002-7331-1382Unclaimed ORCID profile · follow to get notified of new preprints

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Jing Xue6 papers · Xuzhou Medical College

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Weizhong ZengiD· 2 shared Youxing JiangiD· 2 shared Cao Mi· 1 shared Chao ZhengiD· 1 shared Deqiang YaoiD· 1 shared Futang WaniD· 1 shared Huaisheng Lu· 1 shared Jianmin WuiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

Weizhong ZengORCID

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3 papers

Recent·Most cited

Molecular mechanisms of mitochondrial Ca2+ exchanger NCLX

Li Zhang, Yan Han, Weizhong Zeng, Jing Xue, Yan Wang, Youxing Jiang

This study reports cryo-EM structures of rat NCLX in different states, revealing its ion exchange mechanism and structural similarities to NCXs.

Nature Communications · Jul 10, 2026Peer-reviewedBiophysics

Structural basis of substrate recognition and allosteric inhibition in human B0AT2

Yunlei Cao, Yunlong Cao, Deqiang Yao, Shaobai Li, Q Wang, Shaohua Shi, Futang Wan, Mingyue Li, Sijia Huang, Huaisheng Lu, Qin Yang, Cao Mi, Yafeng Shen, Chao Zheng, Shanshuang Chen, , Ming Lei

This study determines cryo-EM structures of B0AT2 to elucidate substrate recognition and allosteric inhibition mechanisms, revealing conserved intracellular cavities across SLC6 transporters.

bioRxiv · Jun 24, 2026 · PreprintBiophysics

Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

Jing Xue, Weizhong Zeng, Scott John, Nicole Attiq, Michela Ottolia, Youxing Jiang

This study presents cryo-EM structures of human NCX1 with PIP2 and SEA0400, revealing how these molecules modulate NCX1 activity through conformational changes.

bioRxiv · Dec 5, 2024Biophysics