Mariko Sasaki

This study shows Rad27/FEN1 prevents rDNA instability by processing Okazaki fragments, avoiding copy number changes in yeast.

The paper shows that Sir2 suppresses transcription near arrested replication forks in yeast rDNA to prevent copy number changes by directing DSB repair away from HR.

This study shows that Tsa1 stabilizes the rDNA cluster in budding yeast, preventing rDNA instability and extending lifespan.

This study shows that CAF-1 prevents Rad52-mediated rDNA instability during replication-coupled DNA repair in budding yeast by regulating replication fork arrest and resection.

This study identifies Spt4 as a factor that accelerates cellular senescence by promoting non-coding RNA transcription in rDNA clusters, leading to genomic instability and reduced lifespan in yeast.

This study shows that Clb5 promotes rDNA stability by maintaining replication initiation efficiency, reducing recombination-dependent instability at replication fork barriers.