Author

Annapaola Franchitto

Istituto Superiore di SanitàORCID 0000-0003-4232-4727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Pietro PichierriiD· 3 shared Pasquale ValenzisiiD· 2 shared Alfredo PagliucaiD· 1 shared Benedetta Perdichizzi· 1 shared Daniela Merlo· 1 shared Elena Roscioli· 1 shared Eva MalacariaiD· 1 shared Flavia Di Feo· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

Pietro PichierriORCID

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3 papers

Recent·Most cited

A novel imaging biosensor for the detection of reversed replication forks and four-way junctions in human cells

Eva Malacaria, Elena Roscioli, Annapaola Franchitto, Pietro Pichierri

The paper introduces a biosensor to detect reversed replication forks and four-way junctions in human cells, enabling spatial analysis of DNA structures in situ.

bioRxiv · Aug 24, 2026 · PreprintCell Biology

Subthreshold perturbation of DNA replication induces a secretory response and a bystander effect in naïve human fibroblasts

Benedetta Perdichizzi, Floriana Cappiello, Flavia Di Feo, Loredana Le Pera, Alfredo Pagliuca, Pasquale Valenzisi, Marco Rosina, Daniela Merlo, Annapaola Franchitto, Pietro Pichierri

The paper shows that low-dose DNA replication perturbation in fibroblasts triggers a secretory response and bystander effect without DNA damage.

bioRxiv · Aug 21, 2026 · PreprintCell Biology

WRNIP1-ATM signaling promotes G-quadruplex resolution by preserving FANCJ stability

Pasquale Valenzisi, Rosa Parrillo, Pietro Pichierri, Annapaola Franchitto

This study identifies a WRNIP1-ATM-FANCJ pathway that resolves G-quadruplexes by stabilizing FANCJ, preventing genome instability.

bioRxiv · Jul 3, 2026 · PreprintCell Biology