Maya M. Arce

The paper identifies cis-regulatory elements and transcription factors controlling FOXP3 expression in human Tregs and Tconvs, revealing mechanisms that restrict FOXP3 to Tregs in mice.

This paper performs in vivo CRISPR screens in human T cells to identify genetic modifiers of T cell function in solid tumors, finding P2RY8-G13 and GNAS as key regulators.

This study uses CRISPR perturbations in CD4+ T cells to infer a gene regulatory network, revealing trans-regulatory mechanisms linking immune GWAS genes to signaling pathways.

The paper develops a Bayesian model and software for analyzing CRISPR screens and validates its effectiveness in maintaining statistical power under low coverage conditions.

The paper describes the development of a gastric cancer registry integrating clinical and genomic data to support translational research.