Julia C. Carnevale

This paper develops a virus-like particle-based system for CRISPR gene editing and screening in primary human myeloid cells, identifying TNFAIP3 as a key regulator of inflammatory polarization.

This paper develops a non-viral BCMA CAR-T therapy using CRISPR and 1XX signaling, showing improved safety, potency, and persistence in multiple myeloma.

This study uses base-editing to inactivate a missense mutation in A20ZF7, enhancing CAR-T cell efficacy by reducing exhaustion and improving anti-tumor responses.

This paper performs in vivo CRISPR screens in human T cells to identify genetic modifiers of T cell function in solid tumors, finding P2RY8-G13 and GNAS as key regulators.

This paper introduces a segmentation-free method to analyze live-cell imaging data of T cell-cancer cell interactions, revealing how T cell modifications affect aggregate formation dynamics.

This study uses explainable AI to analyze live-cell imaging data and identify behavioral changes in TCR T cells with specific genetic knockouts.

The paper develops tools for analyzing T cell behavior from live-cell imaging to improve T cell therapies by studying the effects of genetic modifications on T cell-cancer cell interactions.

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.