Luca Guglielmi

This study develops a method to generate forebrain organoids with macroscale geometry resembling the developing telencephalon, showing enlarged ventricles and delayed maturation in human compared to mouse.

This study develops a cerebellar organoid model to compare development across species and identifies species-specific size differences and gene expression patterns.

The paper shows that Nodal signaling creates a temporal window for stochastic cell fate switching in zebrafish embryos, challenging deterministic models of morphogen action.

The paper introduces an improved Erk biosensor to study Erk signaling dynamics in zebrafish and Drosophila embryos, revealing oscillatory dynamics driven by mitotic erasure.