Marc Amoyel

Somatic cells compartmentalise their metabolism to sustain germ cell survival

The paper shows that somatic gonadal cells in testes break down sugars to produce lactate for germ cell survival, highlighting metabolic compartmentalization as essential for germline maintenance.

Licensing and competition of stem cells at the niche combine to regulate tissue maintenance

The paper develops stochastic models to show that licensing and competition for niche access together regulate stem cell homeostasis and prevent extinction.

Niche signalling regulates eIF3d1 phosphorylation to promote distinct modes of translation initiation in stem and differentiating cells

The paper shows that niche signals regulate eIF3d1 phosphorylation to control translation initiation in stem and differentiating cells, enabling distinct translational programs.

An improved Erk biosensor reveals oscillatory Erk dynamics driven by mitotic erasure during early development

The paper introduces an improved Erk biosensor to study Erk signaling dynamics in zebrafish and Drosophila embryos, revealing oscillatory dynamics driven by mitotic erasure.

A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila

The paper develops a kinase translocation reporter to monitor ERK activity in real-time in Drosophila and identifies novel dynamics in ERK signaling during development.

Cell cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis

The paper shows that E2f1/Dp activity regulates mitochondrial activity in Drosophila CySCs, linking cell cycle exit and differentiation.

Stem cells commit to differentiation following multiple induction events in the Drosophila testis.

The paper shows that Drosophila cyst stem cells (CySCs) require multiple signals, including germline interaction and PI3K/Tor pathway activation, to commit to differentiation.

An immobilization technique for long-term time-lapse imaging of explanted Drosophila tissues

This paper introduces a technique to immobilize Drosophila tissues for long-term live imaging, enabling detailed observations of cellular and tissue dynamics.