Teele Palumaa

The paper introduces a novel genetically diverse mouse model of naturally occurring refractive error (NORE) with three distinct refractive phenotypes, offering a tool for studying genetic and environmental factors in refractive errors without inducing myopia through interventions.

The paper identifies genetic variants associated with diurnal glucose levels and their role in type 2 diabetes risk.

This study shows that circadian misalignment contributes to myopia across species, with reversible effects in mice and associations in human populations.

The paper identifies widespread 24-hour gene expression rhythms in human tissues using local phase inference, revealing previously underestimated rhythmic transcription in the brain and associations with neurodegenerative diseases.

This study shows treadmill exercise reduces inflammation and alters miRNA expression in a light-induced retinal degeneration model, preserving retinal function and photoreceptor density.

The paper uses Estonian Biobank data to identify genetic loci associated with 5,491 disease phenotypes, finding 3,222 genome-wide significant loci and 754 protein-altering variant-trait associations.

This study shows that α-lipoic acid can normalize copper metabolism in Alzheimer's disease by increasing intracellular copper levels and reducing disease symptoms in a Drosophila model.

This study shows that SIK1 activity modulates synaptic phosphoproteome to induce sleep independently of sleep pressure, revealing a causal mechanism for sleep regulation.