Machelle T. Pardue

The paper introduces a novel genetically diverse mouse model of naturally occurring refractive error (NORE) with three distinct refractive phenotypes, offering a tool for studying genetic and environmental factors in refractive errors without inducing myopia through interventions.

This study shows that circadian misalignment contributes to myopia across species, with reversible effects in mice and associations in human populations.

This study shows L-DOPA treatment sustains neurovascular and synaptic function in diabetic retinas, with effects lasting after treatment ends.

The paper measures all-trans retinoic acid (atRA) concentrations in mice and develops a model to understand its transport and role in myopia development.

This study examines how treadmill exercise affects retinal vascular morphology, function, and immune factors in a mouse model of retinal degeneration, finding improved vascular health and immune response profiles in exercised mice.

This study shows treadmill exercise reduces inflammation and alters miRNA expression in a light-induced retinal degeneration model, preserving retinal function and photoreceptor density.

This study investigates how ambient light and dopamine affect all-trans retinoic acid levels in the mouse eye, finding that light exposure reduces atRA and that dopamine influences atRA levels.

This study evaluates a fluorescent analog of all-trans retinoic acid as a surrogate for studying its transport and distribution in ocular tissues.

This paper shows treadmill exercise increases retinal astrocyte complexity and BDNF interactions, protecting against light-induced retinal degeneration.

This study shows that developmental circadian disruption in mice alters placental gene expression and immune cell markers, potentially increasing adult chronic disease risk.

The paper investigates visual perception impairments in a mouse model of autism, finding reduced excitatory and increased inhibitory activity in the visual cortex during sensory tasks.

This study compares the effects of two adrenoreceptor antagonists on reversing ketamine/xylazine anesthesia in mice, finding that atipamezole accelerates certain emergence behaviors more effectively than yohimbine.