Zachary Drum

One hour of 200 mM sorbitol collapses most chromatin loops in human cells while several hundred transient, cohesin-dependent, CTCF-independent loops form at active promoters, preceding anchor-gene activation.

This study investigates how NUP98-HOXA9 drives aberrant chromatin looping in AML by interacting with CTCF and cohesin, revealing a non-canonical mechanism involving phase separation and loop extrusion.

The paper analyzes gene expression in Drosophila sechellia fed noni fruit to identify genetic mechanisms underlying toxin resistance and diet specialization.

This study compares the transcriptional responses of Drosophila species to hexanoic acid exposure, identifying D. sechellia-specific gene regulation associated with dietary specialization.