Author

Tooba Rashid

University of North Carolina at Chapel HillORCID 0000-0002-9183-2982Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CUT&Tag· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Doris Cruz AlonsoiD· 2 shared Douglas H. PhanstieliD· 2 shared Gang Greg WangiD· 2 shared Gelila PetrosiD· 2 shared Ivana Yoseli QuirogaiD· 2 shared Jill M. DoweniD· 2 shared Zachary DrumiD· 2 shared Andrea A. PerreaultiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersGenomics

Doris Cruz AlonsoORCID

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2 papers

Recent·Most cited

Hyperosmotic stress induces rewiring of 3D chromatin interactions

John Patrick Flores, Andrea A. Perreault, Zachary Drum, Chenxi Xu, Doris Cruz Alonso, Tooba Rashid, Jeremy D. Burgess, Geoffrey Fox, Gelila Petros, Yijia Wu, Ivana Yoseli Quiroga, HyunAh Kim, Isha R Sahasrabudhe, Ye Jin Lee, Ethan Black, , Douglas H. Phanstiel

One hour of 200 mM sorbitol collapses most chromatin loops in human cells while several hundred transient, cohesin-dependent, CTCF-independent loops form at active promoters, preceding anchor-gene activation.

bioRxiv · Oct 9, 2026 · PreprintGenomics✦ In-depth digest

Aberrant chromatin looping by NUP98-HOXA9 is constrained by CTCF and facilitated by cohesin

Tooba Rashid, Zachary Drum, Ivana Yoseli Quiroga, Doris Cruz Alonso, Gelila Petros, Eric Davis, Benjamin Kornegay, Chelsea Yang, Chenxi Xu, Sylvie M. Parkus, Gang Greg Wang, Wesley R. Legant, Jill M. Dowen, Douglas H. Phanstiel

This study investigates how NUP98-HOXA9 drives aberrant chromatin looping in AML by interacting with CTCF and cohesin, revealing a non-canonical mechanism involving phase separation and loop extrusion.

bioRxiv · Jun 23, 2026 · PreprintMolecular Biology