Author
University of North Carolina at Chapel HillORCID 0000-0001-9776-1989Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
John Patrick Flores, Andrea A. Perreault, Zachary Drum…·Douglas H. Phanstiel
One hour of 200 mM sorbitol collapses most chromatin loops in human cells while several hundred transient, cohesin-dependent, CTCF-independent loops form at active promoters, preceding anchor-gene activation.
Tooba Rashid, Zachary Drum, Ivana Yoseli Quiroga…·Douglas H. Phanstiel
This study investigates how NUP98-HOXA9 drives aberrant chromatin looping in AML by interacting with CTCF and cohesin, revealing a non-canonical mechanism involving phase separation and loop extrusion.
Ricardo J Mack, Natasha Mahealani Flores, Geoffrey Fox…·Or Gozani
This study shows SETD2 suppresses lung cancer in a KRASG12C model and its activity is regulated by histone acetylation and ubiquitination.
Geoffrey Fox, Karl F. Poncha, B Rutledge Smith…·Kanishk Jain
The paper shows that H3K18 and H3K23 acetylation enhance MLL1-mediated H3K4 methylation, while other modifications are less affected by tail acetylation.
Cyril S. Anyetei‐Anum, Mary P Leatham-Jensen, Geoffrey Fox…·Daniel J. McKay
The paper shows that H3.2K4 antagonizes Polycomb group activity and promotes target gene expression in vivo.
Aki K. Braceros, Megan D. Schertzer, Arina D. Omer…·J. Mauro Calabrese
The paper shows that the lncRNA Airn recruits Polycomb Repressive Complexes to silence genes during mouse embryogenesis through chromatin contacts and regulatory elements.