Guy W. Dayhoff

The paper quantifies compositional patterns in SRY proteins and HMG-box domains across mammals, revealing distinct compositional grammars and highlighting the need for alignment-independent analysis.

This paper introduces AiPP, an AI-based platform for predicting ligandable sites in the human proteome, and demonstrates its application in discovering covalent inhibitors for PTPN6.

This study shows CDKN1A stabilizes cyclin D3 by inhibiting its phosphorylation-dependent nuclear export after butyrate treatment, revealing a mechanism for butyrate-induced cell cycle arrest.

This paper introduces KaML-ESM2 and KaML-ESMC models to predict protein pKa values, outperforming existing methods but facing challenges with engineered residues.

This study analyzes human moonlighting proteins using phylogenetic methods to explore their distal-proximal relationships and identify evolutionary hotspots.

The paper analyzes the role of intrinsically disordered proteins/regions in aging-related processes, finding they are prevalent in genome regulation and associated with aging hallmarks.

This study analyzes the ORF8 protein of SARS-CoV-2 and its mutations across human, bat, and pangolin hosts to understand its role in immune evasion and evolutionary dynamics.

The paper analyzes variations in SARS-CoV-2 accessory proteins across global proteomes and finds ORF3a has the highest unique variations, suggesting these variations may influence pathogenicity.