Harrison K. Wang

The paper develops open-source software to analyze symmetry breaking in macromolecular crystallography under vectorial perturbations and applies it to three time-resolved experiments.

The paper shows that chaperonin GroEL/S promotes drug resistance by recognizing protein dynamics, displacing inhibitors and restoring active enzyme function.

This paper introduces a statistical method to estimate excited-state structure factors in perturbative crystallography, improving upon traditional extrapolation by accounting for correlations between ground and excited states.

This paper improves the detection of protein dynamics and drug fragment binding by combining a Bayesian framework with multivariate statistical theory for comparative crystallography.

This paper applies variational inference to time-resolved diffraction data of an enzyme to extract high signal-to-noise changes in electron density and evaluates hyperparameter impact.

Laue-DIALS is an open-source software pipeline for analyzing polychromatic X-ray diffraction data, enabling efficient processing and integration of diffraction intensities with wavelength correction.