Qiming Zhang

This study shows that dietary cysteine improves intestinal stem cell repair through IL-22 from CD8+ T cells.

This study shows that PPARγ downregulation in colonic CD8+ T cells of people with HIV on ART leads to epithelial barrier disruption by promoting lipid uptake and apoptosis.

The paper shows that colitis leaves an epigenetic memory in colonic stem cells that promotes tumor growth by enhancing regenerative gene programs and AP-1 activity.

This study directly compares 10X Genomics Chromium and Smart-seq2 scRNA-seq platforms, finding differences in gene detection, noise, dropout rates, and differential expression, with recommendations for platform selection based on study goals.

This paper introduces CSOmap, a computational method to infer spatial organization from scRNA-seq data, successfully reconstructing tumor microenvironments and simulating perturbations to study cellular interactions.