This study compares the metabolic states of Mycobacterium tuberculosis in human and mouse macrophages, revealing species-specific lipid metabolism and identifying a barrier to lipid access in human macrophages.

mSphere · Jun 29, 2026Peer-reviewedMicrobiology

Citrate Compartmentalization Controls Calcium-Dependent Cytokine Production in Effector T Cells

Andrea L Cote, Claire McIntyre, Joshua A. Acklin, Lillian R. Delacruz, Yunping Qiu, Irwin J. Kurland, Alison Epstein Ringel

This study shows that citrate compartmentalization regulates calcium-dependent cytokine production in effector T cells by linking glucose availability to calcium signaling.

bioRxiv · Jun 12, 2026 · PreprintImmunology

MARBL: A Live-Cell Method for Profiling Bioenergetic Heterogeneity by Noncanonical Methionine Labeling of the Cell Surface Proteome

Lillian R. Delacruz, Ming Ye, Kendra A. Libby, Keran Han, Chad J. Munger, YUNPING QIU, Irwin J. Kurland, Alison Epstein Ringel

MARBL profiles bioenergetic heterogeneity in live cells by noncanonical methionine labeling of the surface proteome, revealing metabolic resilience differences between immune cell types.

bioRxiv · Jun 2, 2026 · PreprintCell Biology

PPARγ downregulation in colonic CD8+ T cells results in epithelial barrier disruption in people with HIV on antiretroviral therapy

Upasana Das Adhikari, Leah M. Froehle, Alexandra N. Pipkin, Heeva Baharlou, Alice H. Linder, Palak Shah, Amanda M. Hussey, Qiming Zhang, Sarah K. Nyquist, Saleh Khawaled, Fangtao Chi, Swagata Goswami, Sabhyata Sedhain, Salina Hussain, Thomas J. Diefenbach, , Douglas S. Kwon

This study shows that PPARγ downregulation in colonic CD8+ T cells of people with HIV on ART leads to epithelial barrier disruption by promoting lipid uptake and apoptosis.

Cell · Sep 11, 2025Peer-reviewedImmunology