Author

Melanie Eschborn

BioNTech (Germany)ORCID 0000-0003-4287-2678Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aravind MeyyappaniD· 2 shared David MendelowitziD· 2 shared John R. BetheaiD· 2 shared Kelly TammeniD· 2 shared Manushri DalviiD· 2 shared Matthew W. KayiD· 2 shared Pranav PrasooniD· 2 shared Sreejita ArnabiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Aravind MeyyappanORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintJul 23, 2026

TNFR2 Agonism as a Sex-Specific Therapy for Novel Osteoarthritis-Induced Cardiac Dysfunction

Pranav Prasoon, Kelly Tammen, Rebekah Russo…·John R. Bethea

This study shows that TNFR2 agonism can prevent and reverse OA-induced cardiac dysfunction in female mice and delay systolic decline in males, revealing sex-specific cardiac effects of OA.

DOI 10.64898/2026.07.06.736778

mouseexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintOct 16, 2025

Sex-Specific Characterization of a Novel Osteoarthritis-Induced Heart Failure Model in Mice

Pranav Prasoon, Kelly Tammen, Aravind Meyyappan…·John R. Bethea

This study characterizes a novel mouse model of OA-induced heart failure, revealing sex-specific cardiac remodeling and molecular pathways associated with different HF phenotypes.

DOI 10.1101/2025.10.16.682846

mouseproteomics

𝕏 PostBluesky