Pranav Prasoon

TNFR2 Agonism as a Sex-Specific Therapy for Novel Osteoarthritis-Induced Cardiac Dysfunction

This study shows that TNFR2 agonism can prevent and reverse OA-induced cardiac dysfunction in female mice and delay systolic decline in males, revealing sex-specific cardiac effects of OA.

Sex-Specific Characterization of a Novel Osteoarthritis-Induced Heart Failure Model in Mice

This study characterizes a novel mouse model of OA-induced heart failure, revealing sex-specific cardiac remodeling and molecular pathways associated with different HF phenotypes.

Aligning with the predecessors and counterarguments: A systematic review of the anatomical correlates for the newly discovered meningeal layer in the existing literature

This paper systematically reviews existing literature to determine if prior descriptions of a newly discovered meningeal layer exist, finding structural evidence in eight studies but limited clear descriptions.

Endogenous μ-opioid - neuropeptide Y Y1 receptor synergy silences chronic postoperative pain

The paper shows that MOR and Y1R receptor synergy in spinal cord interneurons reduces postoperative hyperalgesia and ongoing pain after surgery.

NRP1 and furin as putative mediators of SARS-CoV-2 entry into human brain cells

The paper investigates the role of NRP1 and furin in SARS-CoV-2 entry into human brain cells using transcriptomic and proteomic data from public databases.

Fast A-type currents shape a rapidly adapting form of delayed short latency firing of excitatory superficial dorsal horn neurons that express the NPY Y1 receptor

The paper characterizes firing patterns of Y1eGFP neurons in the spinal cord and finds they exhibit delayed short-latency firing under hyperpolarized conditions, associated with fast A-type potassium currents and T-type calcium channel activity.