Author

James P Held

Vanderbilt UniversityORCID 0000-0003-4322-2108Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Maulik R. PateliD· 3 shared Lantana K. GrubiD· 2 shared Samantha H. SchaffneriD· 2 shared Adrianna M. StrozakiD· 1 shared Bharat Vivan ThapaiD· 1 shared Evi M. MalagiseiD· 1 shared Hayeon Ryou· 1 shared Marleigh R. Canter· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenetics

Maulik R. PatelORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintFeb 3, 2025

Loss of an uncharacterized mitochondrial methionine tRNA-synthetase induces mitochondrial unfolded protein response in Caenorhabditis elegans

Bharat Vivan Thapa, Mohit Das, James P Held, Maulik R Patel

The paper identifies a mutation in the gene Y105E8A.20 that causes mitochondrial unfolded protein response in C. elegans by impairing methionine tRNA synthetase activity.

DOI 10.1101/2025.02.03.636310

C. elegansexperimental assay

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Cell BiologybioRxivPreprintMay 20, 2024

Germline status and micronutrient availability regulate a somatic mitochondrial quality control pathway via short-chain fatty acid metabolism

James P Held, Nadir H Dbouk, Adrianna M. Strozak…·Maulik R Patel

This study shows that germline signals regulate somatic mitochondrial quality control through short-chain fatty acid metabolism and micronutrient availability in C. elegans.

2 citations

C. elegansproteomics

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GeneticsbioRxivPreprintMar 27, 2023

A role for N6-methyldeoxyadenosine in C. elegans mitochondrial genome regulation

Lantana K. Grub, James P Held, Tyler J. Hansen…·Maulik R. Patel

The paper identifies N6-methyldeoxyadenosine (6mA) as an epigenetic mark in C. elegans mtDNA, showing its dynamic regulation and link to mitochondrial function.

3 citations

C. eleganswhole-genome sequencing

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