Author

Bharat Vivan Thapa

Van Andel InstituteORCID 0000-0002-5269-2139Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam J. HrubyiD· 1 shared Aeowynn J. CoakleyiD· 1 shared Anna Entin· 1 shared Athena AlcalaiD· 1 shared Daniel HicksiD· 1 shared Elijah A. Roditi· 1 shared Gilberto GarciaiD· 1 shared James P HeldiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenetics

Adam J. HrubyORCID

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2 papers

Recent·Most cited

Expression of tardigrade intrinsically disordered proteins in C. elegans reveals variable effects on aging and stress

Anna Entin, Daniel Hicks, Elijah A. Roditi, Juri Kim, Aeowynn J. Coakley, Adam J. Hruby, Athena Alcala, Naibedya Dutta, Maxim Averbukh, Shivay Parihar, Rebecca Aviles Barahona, Thomas Jiyoung Lee, Veronica Kuo, Vinaya Sahasrabuddhe, Bharat Vivan Thapa, , Ryo Higuchi‐Sanabria

Constitutive somatic expression of four tardigrade disordered proteins shortened C. elegans lifespan and healthspan and gave little stress protection. Three of the four reduced polyQ aggregation under hyperosmotic stress.

bioRxiv · Oct 31, 2026 · PreprintGenetics✦ In-depth digest

Loss of an uncharacterized mitochondrial methionine tRNA-synthetase induces mitochondrial unfolded protein response in Caenorhabditis elegans

Bharat Vivan Thapa, Mohit Das, James P Held, Maulik R Patel

The paper identifies a mutation in the gene Y105E8A.20 that causes mitochondrial unfolded protein response in C. elegans by impairing methionine tRNA synthetase activity.

bioRxiv · Feb 3, 2025 · PreprintGenetics