William Lai

The paper uses a multi-modal platform to profile single-cell stress responses in human cell lines, finding a shared stress response program with cell-specific magnitude variations.

ScriptManager v1.0 provides a unified framework for reproducible and scalable analysis of genomics and epigenomics data across diverse assays.

This paper optimizes liquid chromatography conditions for single-cell proteomics across platforms, demonstrating its effectiveness even on non-specialized instruments and showing its ability to detect biological responses to oxidative stress.

The paper develops containerized solutions and an optimized platform for protein structure prediction and design tools to improve accessibility and computational efficiency.

GenoPipe identifies the genotype of origin in genomic datasets by analyzing unique markers to validate and correct experimental errors.

The paper investigates how sequence preferences and chromatin environments influence Fox TF binding using neural networks and mouse stem cells.

PEGR is a web-based platform that manages epigenomic and genomic research projects, ensuring reproducibility across experimental and computational workflows.

STENCIL is a web templating engine that organizes, visualizes, and shares life science datasets, enabling interactive and customizable data dissemination.

This study investigates how Ssl2/TFIIH influences transcription start site scanning by RNA Polymerase II in yeast, identifying alleles that alter TSS selection and scanning processivity.

The paper investigates promoter scanning by Pol II in yeast, showing that it occurs across all promoters and is influenced by Pol II activity and promoter architecture.

The paper introduces ChExMix, a method to detect and classify distinct protein-DNA binding subtypes in ChIP-exo data using probabilistic modeling of tag distributions and DNA motifs.