Prototype mRNA vaccines imprint broadly neutralizing human serum antibodies after Omicron variant-matched boosting
Chieh-Yu Liang, Saravanan Raju, Zhuoming Liu…·Michael S. Diamond
This study shows that Omicron variant-matched boosters after prototype mRNA vaccines induce cross-neutralizing antibodies against SARS-CoV-2 and sarbecoviruses by imprinting prior immune responses.