Mark G. Lewis

The paper shows that in chronic SIV infection, viral RNA is mainly found in B-cell follicles of lymphatic tissues, leading to structural damage and sustained virus-host interactions.

The paper shows that early clonal dominance in B-cell precursors after vaccination predicts the breadth of HIV-neutralizing antibodies in rhesus macaques.

AAV-delivered broadly neutralizing antibodies provide durable protection against SIV challenge in rhesus macaques, while ADCC-only antibodies do not.

This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.

This study examines SIV dissemination in rhesus macaques after rectal infection, showing systemic infection occurs without local viral amplification at the entry site.

This study shows a novel two-step mechanism for inducing broadly neutralizing HIV antibodies in macaques using a modified SHIV, informing vaccine design.

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

This study shows that ZIKV-117, a neutralizing monoclonal antibody, provides complete protection against ZIKV challenge in rhesus macaques at a low dose.

This study investigates how clonal hematopoiesis affects COVID-19 severity and pathophysiology in rhesus macaques, finding prolonged inflammation and higher viral persistence in CH animals.

This paper describes an engineered SARS-CoV-2 RBD variant that shows improved immunogenicity in mice and protective immunity in hamsters.