Gregory Handy

Boundary homogenization and numerical modeling of solute transport across the blood-brain barrier

This study develops a novel boundary condition for modeling Aβ transport across the BBB, showing its sensitivity to receptor ratios and blood clearance rates during sleep and pathological conditions.

Extending mathematical frameworks to investigate neuronal dynamics in the presence of microglial ensheathment

This paper extends mathematical models to study how microglial ensheathment affects synaptic communication and network dynamics, showing it can switch off connections and lead to post-anesthesia hyperactivity in mice.

The mechanics of correlated variability in segregated cortical excitatory subnetworks

The paper investigates correlated variability in segregated cortical networks and finds that excitatory-inhibitory functional assemblies explain enhanced correlations.

The logic of recurrent circuits in the primary visual cortex

The paper investigates how recurrent circuits in the primary visual cortex influence visual perception by analyzing the spatial arrangement and feature preferences of neuronal ensembles.

Investigating the ability of astrocytes to drive neural network synchrony

This paper develops an effective astrocyte model to study how astrocytic ensheathment influences neuronal network synchronization and collective dynamics.

Cortical VIP neurons locally control the gain but globally control the coherence of gamma band rhythms

The paper shows VIP neurons scale local gamma oscillation gain and suppress global gamma coherence based on stimulus properties and retinal image statistics.

Cell-type-specific roles of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage

The paper investigates how inhibitory interneurons contribute to auditory cortex plasticity after peripheral damage, revealing cell-type-specific roles in restoring sound processing.