Kiarash Shamardani

Neural signatures of glioma progression using implanted neural interfaces

Microwire recordings in glioma-bearing mice track tumor progression: gamma power rises in glioblastoma and diffuse intrinsic pontine glioma xenografts, and low-gamma trajectories predict tumor growth rate (R^2 0.63).

Juvenile influenza can impair myelin development and adult behavior through chemokine signaling in mice

This study shows that juvenile influenza infection in mice impairs myelin development and leads to lasting cognitive and behavioral issues, which can be mitigated by inhibiting the chemokine receptor CCR3.

Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma

This study investigates how microglial synaptic engulfment is dysregulated in diffuse midline glioma, leading to imbalanced excitatory-inhibitory synapse ratios and increased neuronal hyperexcitability.

Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology

This study shows serotonergic neurons promote high-grade glioma growth via 5HT2A receptor activation, with psychedelic drugs enhancing this effect.

Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

This study shows that cholinergic neuron activity promotes both healthy OPC and DMG proliferation through muscarinic receptors, with specific nuclei driving growth in different brain regions.

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

This study shows that CAR T cell therapy in mice causes cognitive impairment through CNS immune dysregulation, microglial reactivity, and disrupted oligodendroglial homeostasis.

GABAergic neuron-to-glioma synapses in diffuse midline gliomas

This study identifies functional GABAergic neuron-to-glioma synapses in diffuse midline gliomas that promote tumor proliferation and shows that drugs modulating GABAergic signaling affect glioma growth.

Myelin plasticity in ventral tegmental area is required for opioid reward

The paper shows that myelin plasticity in the ventral tegmental area, regulated by dopaminergic activity, is essential for opioid reward and dopamine release dynamics.

The logic of recurrent circuits in the primary visual cortex

The paper investigates how recurrent circuits in the primary visual cortex influence visual perception by analyzing the spatial arrangement and feature preferences of neuronal ensembles.

Glioma synapses recruit mechanisms of adaptive plasticity

This study shows that BDNF-TrkB signaling promotes malignant synaptic plasticity in gliomas, enhancing tumor progression through mechanisms similar to long-term potentiation in the healthy brain.