Author

Christina M. Kajba

The Francis Crick InstituteORCID 0000-0002-7896-0744Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:CRISPR screen· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Gregory M. FindlayiD· 2 shared Megan BuckleyiD· 2 shared Ana Cunha· 1 shared Athina GanneriD· 1 shared Chelsea SawyeriD· 1 shared Chloé TerwagneiD· 1 shared Dong‐Kyu KimiD· 1 shared Elke Neumann‐HaefeliniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Gregory M. FindlayORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

High-throughput screening of human genetic variants by pooled prime editing

Michael Herger, Christina M. Kajba, Megan Buckley, Ana Cunha, Molly Strom, Gregory M. Findlay

This paper introduces a pooled prime editing platform in haploid human cells to assess the functional effects of genetic variants, showing high accuracy in identifying loss-of-function variants and pathogenic non-coding variants.

Cell Genomics · Mar 22, 2025Peer-reviewedGenomics

Saturation Genome Editing Resolves the Functional Spectrum of Pathogenic VHL Alleles

Megan Buckley, Chloé Terwagne, Athina Ganner, Laura Cubitt, Reid A. Brewer, Dong‐Kyu Kim, Christina M. Kajba, N. Forrester, Phoebe Dace, Joachim De Jonghe, Scott T.C. Shepherd, Chelsea Sawyer, Mairead McEwen, Sven Diederichs, Elke Neumann‐Haefelin, , Gregory M. Findlay

This study uses Saturation Genome Editing to functionally assess VHL variants, identifying pathogenic alleles and their mechanisms in cancer.

Nature Genetics · Jul 1, 2024Peer-reviewedGenomics