Author

Ana Cunha

The Francis Crick Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Molly StromiD· 2 shared Ananya BhallaiD· 1 shared Anita E. GrigoriadisiD· 1 shared Carin Andrea Brundin· 1 shared Cheryl GillettiD· 1 shared Christina M. KajbaiD· 1 shared Dinis Pedro CaladoiD· 1 shared Elena Alberts· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Molly StromORCID

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2 papers

Recent·Most cited

Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis

Victoire Boulat, Elena Alberts, Paul C. Driscoll, Miu Shing Hung, Ana Cunha, Jelmar Quist, Fangfang Liu, Carin Andrea Brundin, Ananya Bhalla, Lidia Avalle, James Rosekilly, Lucy Ryan, Cheryl Gillett, Molly Strom, Valeria Poli, , Dinis Pedro Calado

This study identifies lactate as a tumor-secreted metabolite that inhibits B cell chemotaxis and TLS formation in TNBC by disrupting mitochondrial metabolism.

bioRxiv · Aug 30, 2025 · PreprintCancer Biology

High-throughput screening of human genetic variants by pooled prime editing

Michael Herger, Christina M. Kajba, Megan Buckley, Ana Cunha, Molly Strom, Gregory M. Findlay

This paper introduces a pooled prime editing platform in haploid human cells to assess the functional effects of genetic variants, showing high accuracy in identifying loss-of-function variants and pathogenic non-coding variants.

Cell Genomics · Mar 22, 2025Peer-reviewedGenomics