Author

Ayikoe Guy Mensah‐Nyagan

InsermORCID 0000-0003-4454-511XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Hélène Jeltsch‐DavidiD· 3 shared Karim MatmatiD· 3 shared Carole JameyiD· 1 shared Céline KeimeiD· 1 shared Christian KleiniD· 1 shared Daniel BrumaruiD· 1 shared Emmanuel DarcqiD· 1 shared Jean‐Louis GuéantiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

Hélène Jeltsch‐DavidORCID

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3 papers

Recent·Most cited

A severely affected MRL/Lpr mouse exhibits a divergent clinical-immune profile associated with a profound metabolic alteration.

Karim Matmat, Carole Jamey, Noémie Karabacz, Daniel Brumaru, Jerome De Seze, Ayikoe Guy Mensah‐Nyagan, Hélène Jeltsch‐David

The paper describes a severely affected MRL/Lpr mouse with divergent clinical-immune features and profound metabolic alterations, highlighting metabolic dysregulation as a key factor in advanced disease.

Immunology Letters · Sep 25, 2026Peer-reviewedImmunology

IFNγ-associated immune--metabolic remodeling drives serotonin-kynurenine imbalance with cortical vulnerability in lupus-prone mice

Karim Matmat, Rosa‐Maria Guéant‐Rodriguez, Emmanuel Darcq, Okan Baspinar, Jean‐Marc Alberto, Jean‐Louis Guéant, Ayikoe Guy Mensah‐Nyagan, Hélène Jeltsch‐David

This study identifies IFNγ-driven immune-metabolic changes in lupus-prone mice that lead to serotonin-kynurenine imbalance and cortical vulnerability.

bioRxiv · Nov 19, 2025 · PreprintImmunology

Hippocampal multi-layered RNAseq prioritizes oligodendrocyte dysfunction over immune-driven neuroinflammation in neurolupus pathogenesis

Karim Matmat, Christian Klein, Céline Keime, Ayikoe Guy Mensah‐Nyagan, Hélène Jeltsch‐David

The paper identifies oligodendrocyte dysfunction as a key driver of NPSLE pathogenesis, contrasting with immune-driven inflammation in the hippocampus of MRL/Lpr mice.

bioRxiv · Oct 3, 2025 · PreprintNeuroscience