Céline Keime

This study shows that satellite cell glucocorticoid receptor (GR) maintains quiescence but does not mediate therapeutic GC effects on muscle repair, highlighting the importance of treatment timing and context.

This study shows PKA inhibits TRIM28-chromatin binding in ovarian granulosa cells, disrupting ovarian identity through SUMOylation dysregulation.

The paper identifies oligodendrocyte dysfunction as a key driver of NPSLE pathogenesis, contrasting with immune-driven inflammation in the hippocampus of MRL/Lpr mice.

The paper identifies CHD1L as a key regulator of neurodevelopmental processes, showing its role in shaping neuroanatomical and growth phenotypes linked to 1q21.1 copy number variants.

The paper investigates how childhood abuse affects the locus coeruleus-noradrenergic system in post-mortem brain samples, finding reduced neuron density and differential gene expression in resilient individuals.

The paper identifies a protective variant CREB3R119G that reduces ALS risk and progression by modulating CREB3 activity in vulnerable neurons.

The paper uses scRNA-seq and deep learning to map cell cycle gene regulation dynamics in mouse and human cells, identifying key transcription waves and transitions.

This study identifies Rfx6 as a key regulator of enteroendocrine cell differentiation, promoting peptidergic cells while repressing serotonin-producing cells.

The paper identifies early RNA metabolism and splicing alterations in corticospinal neurons in an ALS mouse model, suggesting shared mechanisms across ALS-related genes.