BiochemistrybioRxivPreprint
Enhancing enzymatic bioconjugation efficiency via installation of a substrate recruitment domain
Christopher Shelby, Kaylee P. Kuzelka, Jonathan M. Ellis…·Brian A. Kuhlman
The paper designs a modified tyrosinase enzyme with a substrate recruitment domain to selectively modify tyrosine residues in peptides, enabling efficient bioconjugation of cytotoxic molecules to antibodies.
DOI 10.1101/2025.10.27.684804