Albert A. Bowers

The paper identifies macrocyclic peptides that disrupt the CHD4-GATAD2A interaction in NuRD, revealing CHD4's role as an interaction hub and suggesting a therapeutic strategy for beta-hemoglobinopathies.

This study compares mRNA and yeast display technologies for evaluating ML-designed miniprotein binders, finding mRNA display better enriches slow dissociating binders and achieves higher library coverage.

The paper designs a modified tyrosinase enzyme with a substrate recruitment domain to selectively modify tyrosine residues in peptides, enabling efficient bioconjugation of cytotoxic molecules to antibodies.

This paper uses mRNA display and machine learning to predict substrate promiscuity of the RiPP cyclodehydratase LynD and identify epistatic interactions.