Zhiyuan Yao

This study compares mRNA and yeast display technologies for evaluating ML-designed miniprotein binders, finding mRNA display better enriches slow dissociating binders and achieves higher library coverage.

The paper designs a modified tyrosinase enzyme with a substrate recruitment domain to selectively modify tyrosine residues in peptides, enabling efficient bioconjugation of cytotoxic molecules to antibodies.

This paper designs a water-soluble CD20 mimic using computational methods to enable binding studies and therapeutic development.