Han Chow Chua

The paper establishes a framework to assess NALCN variant pathogenicity using functional and computational methods, distinguishing benign from gain- and loss-of-function variants.

The paper identifies a functional interaction between ASIC1a and MCT1 that modulates proton sensitivity and desensitization, showing its role in glioblastoma cell survival and mouse lifespan.

The paper identifies a rare GJD3 haplotype associated with familial Meniere Disease, showing it disrupts connexin assembly and affects inner ear function.

The paper identifies an unconventional conductance essential for pacemaking in nigral dopamine neurons using pharmacological evidence and electrophysiological analysis.

This paper introduces a method to insert synthetic peptides into proteins in eukaryotic cells to enable chemical modifications and non-canonical amino acids, validated using GFP, NaV1.5, and P2X2 receptors.

This paper identifies the functional requirements of the sodium leak channel complex and shows it is voltage-sensitive and modulated by extracellular calcium.