Author

Søren Østergaard

Novo Nordisk (Denmark)ORCID 0000-0002-9415-3352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Élodie MonsellieriD· 3 shared Gilles TravéiD· 3 shared Renaud VincentelliiD· 3 shared A. Cousido-SiahiD· 2 shared Bastien MorletiD· 2 shared Camille KostmanniD· 2 shared Fabien DurbessoniD· 2 shared Gergő GógliD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Élodie MonsellierORCID

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3 papers

Recent·Most cited

A quantitative interactome map reveals affinity tailored hijacking of human cellular functions by resident and pathogenic bacteria

Jaime Fernandez-Macgregor, Laura Ilari, Fabien Durbesson, Stéphane Audebert, Luc Camoin, Bastien Morlet, Virginie Millet, Jean Michel Dela Vedova-Costa, Charlene Gaedke, Vincent Kourilsky, Lou Bergogne, Eric Martínez, Achille Broggi, Jean‐Paul Borg, Søren Østergaard, , Renaud Vincentelli

The paper reports a large-scale quantitative interactome of human PDZ domains and bacterial PDZ-binding motifs, showing bacteria tailor effector sequences to bind with similar or higher affinity than human PBMs to hijack host functions.

bioRxiv · Oct 5, 2026 · PreprintSystems Biology

The Holdup Multiplex, an assay for high-throughput measurement of protein-ligand affinity constants using a mass-spectrometry readout

François Delalande, Søren Østergaard, Gergő Gógl, A. Cousido-Siah, Alastair G. McEwen, Yushi Men, Farida Salimova, Aurélien Rohrbacher, Camille Kostmann, Yves Nominé, Renaud Vincentelli, Pascal Eberling, Christine Carapito, Gilles Travé, Élodie Monsellier

The paper introduces a high-throughput mass-spectrometry-based assay to measure protein-ligand affinity constants, demonstrating its application to 14-3-3 isoforms and phosphopeptides.

Journal of the American Chemical Society · Mar 25, 2025Peer-reviewedSystems Biology

Quantitative fragmentomics allow affinity mapping of interactomes

Gergő Gógl, Boglárka Zámbó, Camille Kostmann, A. Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Négroni, Pascal Eberling, Pau Jané, Yves Nominé, András Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé

The paper measures affinities of 65,000 PDZ domain interactions using quantitative fragmentomics, revealing viral interference hotspots and system-wide impacts of interactome hijacking.

Nature Communications · Sep 17, 2022Peer-reviewedSystems Biology