Nagireddy Putluri

The paper identifies biallelic KMO variants as a novel cause of congenital NAD deficiency and shows gene x environment interactions in a mouse model.

This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.

This study introduces a scalable organoid model of urothelial aging to investigate metabolic changes and test interventions for age-related bladder dysfunction.

This paper identifies PI3K pathway activation in Nrf2-driven cisplatin-resistant HNSCC and shows that gedatolisib inhibits tumor growth and re-sensitizes cells to cisplatin.

This study shows that AMPK activation prevents HCC by inhibiting HNF4a activity, using genetic and pharmacological models.

This study shows cigarette smoke exposure drives aggressive head and neck cancer by altering oxidative stress response and immunity through Nrf2 activation and metabolic reprogramming.

This study identifies phosphoglycerate mutase (PGAM) as a regulator of Treg differentiation through serine synthesis and one-carbon metabolism, showing its impact on immune suppression and autoimmunity.

This study shows that SMARCA4 regulates spatially restricted metabolic changes in 3D multicellular tissues by altering DNA accessibility and gene expression.