Michael D. Kornberg

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

This study identifies phosphoglycerate mutase (PGAM) as a regulator of Treg differentiation through serine synthesis and one-carbon metabolism, showing its impact on immune suppression and autoimmunity.

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

This study shows TPPB, a new PKC modulator, reduces neuroinflammation and promotes CNS repair in experimental MS by targeting innate immune cells.

The paper shows that bryostatin-1, a PKC modulator, shifts microglia and CNS macrophages from pro-inflammatory to regenerative states, promoting remyelination and neuroprotection in MS.

This study shows that blocking GAPDH nitrosylation with CGP3466b reduces neuroaxonal injury and disability in EAE, a model of multiple sclerosis, without affecting the immune system.

This study identifies biliverdin reductase (BVR) as a bridge between FAK/Pyk2 and Src, showing its role in synaptic signaling and learning/memory deficits in BVR-null mice.

This study identifies D-cysteine as an endogenous regulator of neural progenitor cell dynamics in the mammalian brain, showing its antiproliferative effects and role in cortical development.