Bruce Appel

The paper identifies pre-OPCs in zebrafish spinal cord and shows that Wnt signaling modulation influences oligodendrocyte fate through gene expression and chromatin accessibility.

This study identifies Gsx2 as a regulator of oligodendrocyte precursor cell formation in zebrafish spinal cord through single-cell and single-nuclei multi-omics analyses.

The paper shows Notch signaling epigenetically primes neural progenitors to enhance Sonic Hedgehog signaling and promote oligodendrocyte differentiation in the developing mouse forebrain.

The paper investigates the role of Bdnf-Ntrk2 signaling in spinal cord myelination in zebrafish, finding it contributes but is not essential for myelin formation.

This study creates a zebrafish model with low DHA status to investigate its effects on neurodevelopment and identifies associated morphological and gene expression changes.

This study shows that Cspg4 regulates oligodendrocyte precursor cell morphology in zebrafish without affecting myelin sheath production.

The paper shows that Gephyrin mediates selective myelination of GABAergic and glycinergic axons in zebrafish, with loss of Gephyrin altering myelin placement toward glutamatergic axons.

This study shows that pacemaker interneurons synchronize motor neuron activity in zebrafish embryos through electrical gap junctions, and disruptions in this process are linked to hyperactivity in Fragile X syndrome models.

This study shows that amyloid beta oligomers induce early oligodendrocyte differentiation and dysregulated myelination in zebrafish spinal cords, with PKC as a key mediator.

This study shows the Akt-mTOR pathway promotes myelin sheath growth by regulating cap-dependent translation in zebrafish.

The paper uses single-cell RNA sequencing to identify two distinct progenitor populations in zebrafish spinal cord pMN cells, one producing neurons and the other producing oligodendrocytes, marked by gsx2 expression.

This study shows that Fmrp regulates oligodendrocyte lineage cell specification and differentiation in zebrafish embryos, leading to increased OPCs and reduced OL differentiation in fmr1 mutants.

This study identifies a mutation in the boc gene that disrupts oligodendrocyte formation in zebrafish by affecting Shh signaling maintenance in pMN progenitors.

The paper identifies three 3 UTR motifs that are required for mRNA localization to myelin sheaths in zebrafish.

The paper shows Prdm8 regulates the switch from motor neuron to oligodendrocyte production in zebrafish spinal cord by modulating Shh signaling.

This study shows FMRP promotes myelin sheath growth through local translation regulation in oligodendrocytes, as demonstrated in zebrafish mutants.

This study shows microglia prune myelin sheaths during development, with neuronal activity regulating this process in zebrafish.

This study identifies sequential waves of oligodendrocyte and NG2 cell fate specification in zebrafish spinal cord through distinct levels of Hedgehog signaling and Notch activity.

The paper investigates how synaptic proteins in oligodendrocytes contribute to CNS myelination by analyzing their localization and function during axon ensheathment.