Adhara Gaminde‐Blasco

This study identifies MYRF dysregulation as a mechanism linking Aβ pathology to oligodendrocyte and cognitive impairments in Alzheimer's disease, showing that PKC inhibition can restore myelin and cognition.

This study shows that amyloid beta oligomers induce early oligodendrocyte differentiation and dysregulated myelination in zebrafish spinal cords, with PKC as a key mediator.

This study shows that amyloid-beta oligomers disrupt RNA dynamics in oligodendrocytes by altering hnRNP A2 interactions, leading to increased translation of myelin proteins MBP and MOBP.

This study uses biophysical modeling to explore how nonlinear molecular interactions contribute to neuronal hyperactivity in early Alzheimer's disease, revealing diverse mechanisms that may explain different AD manifestations.