Grant Morahan

Systems genetics identifies ETS1 as a stress-dependent regulator of adipocyte insulin action and heme-iron homeostasis

Genetic variance in the murine defensin locus modulates glucose homeostasis

This study identifies a genetic locus affecting insulin sensitivity in mice, showing that Defa26 modulates glucose homeostasis through microbiome interactions.

Identification of SEC61B as a novel regulator of calcium flux and platelet hyperreactivity in diabetes mellitus

This study identifies SEC61B as a regulator of calcium flux and platelet hyperreactivity in diabetes by linking ER stress to increased SEC61B expression and calcium leak.

Psmd13, a proteosome regulatory subunit identified in miR-29a regulation during neurogenesis

The paper identifies Psmd13 as a regulator of miR-29a during neurogenesis, showing its interaction with Dicer and role in miR-29a expression dynamics.

Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance

The paper identifies small molecules that reverse insulin resistance in mouse skeletal muscle by integrating systems genetics and chemical screening.

Determinants of Murine Skin Microbiota Composition in Homeostasis and Wound Healing

This study shows that host genetics significantly influences murine skin microbiota composition during homeostasis and wound healing, with genetic background explaining most variation in microbiota and healing speed.

Influence of fecal collection conditions and 16S rRNA gene sequencing protocols at two centers on human gut microbiota analysis

This study evaluates how fecal collection conditions and 16S rRNA sequencing protocols affect gut microbiome analysis across two centers, finding that center-specific differences outweigh collection method variations.