Cell BiologybioRxivPreprint
The fibrocystin C-terminal domain inhibits Src/STAT3 signal induced cystogenesis of kidney epithelia.
Fatima Hassan, Susanne T. Hahnenstein, Andre Kraus…·Wolfgang H. Ziegler
This study shows that the fibrocystin C-terminal domain suppresses Src/STAT3 signaling, preventing cyst formation in kidney epithelial cells by inhibiting secretory phenotype and STAT3-dependent transcription.
DOI 10.1101/2025.08.08.669180