Alf Honigmann

This study quantifies lipid sorting during clathrin-mediated endocytosis and finds that lipid asymmetry in the plasma membrane explains observed partitioning, with minimal selectivity for cytoplasmic leaflet lipids compared to non-vesicular trafficking.

The paper identifies lipid specificity in membrane organizing protein complexes by mapping lipid-protein interactions and demonstrating phosphatidylethanolamine's role in stabilizing NDC1 and MIC60.

This study investigates how Tau and Fyn interact to regulate postsynaptic density condensate dynamics, showing that their multivalent interactions cooperatively arrest condensate components.

This study shows that cancer cells adjust their nuclear volumes and proliferation rates during transitions between single and multicellular states in tumor spheroids.

This study investigates how membrane binding influences 2D versus 3D phase separation of the protein FUS, showing that membrane binding allows 2D condensates to form at lower concentrations than bulk phase separation.

This study uses programmable hydrogels to reveal two mechano-sensing timescales in MDCK cells and shows how dynamic mechanical cues influence cell polarity and morphogenesis.

The paper quantifies lipid transport between organelles in mammalian cells, revealing non-vesicular transport as a key mechanism for species-specific lipid sorting.

This paper uses a phase field model to predict organoid morphology by simulating cell division and lumenal pressure, identifying key parameters that determine shape and structure.

This study shows that the fibrocystin C-terminal domain suppresses Src/STAT3 signaling, preventing cyst formation in kidney epithelial cells by inhibiting secretory phenotype and STAT3-dependent transcription.

The paper compares lumen nucleation and fusion dynamics in three epithelial organoid systems under varying hydrostatic pressure conditions, revealing conserved self-organisation rules.

The paper investigates how mechanical properties of curved epithelial tissues respond to deformation, identifying factors like viscoelasticity and cell-cell junctions that influence tissue behavior.

This paper develops a thermodynamic model of non-dilute surface binding and phase separation for membrane-binding proteins and applies it to tight junction formation.

The paper examines how cell-substrate distance fluctuations affect collective migration in confluent monolayers of MDCKII cells and their ZO1/2-depleted variants.

This paper develops a multicellular phase field model to simulate organoid morphology by integrating lumen pressure and cell proliferation, revealing how these factors determine organoid shapes and phenotypes.

This study reveals the molecular structure of primary cilia using cryo-electron tomography, showing a transition from a 9+0 microtubule arrangement to an unstructured bundle of microtubule singlets and actin filaments.