Oscar M. Lazo

This study identifies impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons, linking Rab5 hyperactivation to endosomal dysfunction and ERK1/2 signalling deficits.

This study investigates how botulinum neurotoxin A affects the release of mutant tau in hippocampal neurons, showing it blocks mutant tau release by modulating SNAP25.

This study identifies Rab10 as essential for TrkB sorting and retrograde BDNF signaling in neurons, linking Rab10 to neuroprotection and neurodegeneration.