Adrian R. Ferré-D’Amaré

The paper identifies circular double-stranded DNA as a major component of stress granule cores and shows its requirement for stress granule formation in yeast.

The paper uses machine learning-augmented MD simulations to study ZTP riboswitch ligand interactions, finding that ligand on-rates, not binding affinity, determine activation potency.

The paper develops new purification methods for yeast and human stress granule cores, revealing their discrete nature, variable size, and complex transcriptomic and proteomic composition.