Christopher R. Fullenkamp

Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation.

This paper introduces ATENA, a method using chemically modified CRISPR-Cas9 to target specific G-quadruplexes and i-motifs, showing ligand-dependent transcriptional changes in c-MYC.

Machine learning-augmented molecular dynamics simulations (MD) reveal insights into the disconnect between affinity and activation of ZTPriboswitch ligands

The paper uses machine learning-augmented MD simulations to study ZTP riboswitch ligand interactions, finding that ligand on-rates, not binding affinity, determine activation potency.