Dingding Mo

This paper introduces a thermal cycling transcription method that improves RNA production efficiency and stability, particularly for long and high GC content templates.

This study identifies circAβ-a RNA as a driver of Aβ175 oligomer formation and plaque deposition in sporadic Alzheimer's disease using mouse models and human brain samples.

This study shows that overexpression of circAβ RNA in mice leads to Aβ accumulation and plaque formation, mimicking sporadic AD features and providing a new model for drug development.

This study identifies a circular RNA, circAβ-a, that translates into Aβ175, which is processed into Aβ peptides, revealing an alternative pathway for Aβ biogenesis in Alzheimer's disease.