Juergen Brosius

This paper introduces a thermal cycling transcription method that improves RNA production efficiency and stability, particularly for long and high GC content templates.

This study identifies circAβ-a RNA as a driver of Aβ175 oligomer formation and plaque deposition in sporadic Alzheimer's disease using mouse models and human brain samples.

The paper investigates Alu-driven DNA transductions in primate genomes and finds no evidence of Alu-mediated transductions in humans, chimpanzees, or rhesus monkeys.

This study identifies a circular RNA, circAβ-a, that translates into Aβ175, which is processed into Aβ peptides, revealing an alternative pathway for Aβ biogenesis in Alzheimer's disease.

The paper identifies head-to-tail DNA template insertions in CRISPR/Cas9 editing and highlights the failure of PCR to detect them, advocating for comprehensive analysis.