Lynette J. Tippett

The paper identifies thalamic volume reductions in Alzheimer's disease and shows their utility in classifying cognitive status and reclassifying patients.

This study examines the immunophenotypic and ubiquitination diversity of Huntingtin inclusion bodies in Huntington's disease cerebral cortex, revealing heterogeneity in composition and degradation pathways.

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

The paper investigates the roles of canonical and alternative RPA in CAG repeat diseases, finding that Alt-RPA antagonizes RPA's suppression of CAG expansions, contributing to disease pathogenesis.

This study screens antibodies against huntingtin (Htt) to analyze Htt distribution and aggregates in HD brain tissue, finding correlations between CAG repeat length and Htt aggregation, but not neuronal loss.