The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling
Claudia Carlantoni, Leon M.H. Liekfeld, Sandra A. Hemkemeyer, Danny Schreier, Ceren Saygı, Roberta Kurelić, Silvia Cardarelli, Joanna Maria Kalucka, Christian Schulte, Manu Beerens, Reiner K. Mailer, Tilman E. Schäffer, Fabio Naro, Manuela Pellegrini, Viacheslav O. Nikolaev, , Maike Frye
This study identifies PDE2A as a regulator of lymphatic endothelial development through cGMP-mediated control of Notch signaling, showing its role in junction maturation and cell cycle arrest.
bioRxiv · Jan 18, 2023 · PreprintDevelopmental Biology