Carme Arnan

The paper uses long-read RNA-seq from diverse human populations to reveal ancestry bias in gene annotations and shows improved transcript discovery with personal genome assemblies.

The paper expands the lncRNA catalog using capture long-read RNA sequencing, significantly increasing the number of annotated transcripts in human and mouse genomes.

The paper introduces CapTrap-seq, a method for full-length RNA transcript sequencing, and shows it produces highly accurate transcript models in human tissues.

The paper introduces MapToCleave, a method to profile miRNA biogenesis in living cells, showing that stable lower basal stems enhance processing and expression across species.

The paper identifies weak CEBPA binding in humans as a cause of slower B cell transdifferentiation compared to mice, linked to Alu repeat expansions.

The paper introduces a paired-guide RNA CRISPR-Cas9 system to identify protein-coding and lncRNA genes involved in human B-cell to macrophage transdifferentiation, identifying 26 potential novel genes.

The paper identifies bsAS, an antisense lncRNA, as a regulator of bs/DSRF isoform expression, essential for cell fate determination in Drosophila development.

CRISPETa is a scalable bioinformatic pipeline for designing paired CRISPR guide RNAs for genomic deletion, achieving ≥50% deletion efficiency in tested cases.

The paper traces the evolutionary history of selenophosphate synthetase (SPS) genes, showing how they duplicated and subfunctionalized to acquire distinct roles in metazoans.